Article
A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.
Human molecular genetics - 15 Feb 2011
Gu Jian, Ye Yuanqing, Spitz Margaret R, Lin Jie, Kiemeney Lambertus A, Xing Jingliang, Hildebrandt Michelle A T, Ki Hong Waun, Amos Christopher I, Wu Xifeng
Abstract excerpt
Mutagen sensitivity, a measurement of chromatid breaks induced by various mutagens in short-term cultures of peripheral blood lymphocytes, is an established risk factor for a number of cancers and is highly heritable. The purpose of this study is to identify genetic predictors of mutagen sensitivity. Therefore, we conducted a multi-stage genome-wide association study. The primary scan analyzed 539,437 autosomal...
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