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Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: a genotype-phenotype correlation study.

DNA repair - 10 Oct 2011

Ricceri Fulvio, Porcedda Paola, Allione Alessandra, Turinetto Valentina, Polidoro Silvia, Guarrera Simonetta, Rosa Fabio, Voglino Floriana, Pezzotti Annamaria, Minieri Valentina, Accomasso Lisa, Cibrario Rocchietti Elisa, Orlando Luca, Giachino Claudia, Matullo Giuseppe

Abstract excerpt

DNA double-strand breaks (DSB) are the most lethal form of ionizing radiation-induced DNA damage, and failure to repair them results in cell death. In order to see if any associations exist between DNA repair gene polymorphisms and phenotypic profiles of DSB repair (DSBR) we performed a genotype-phenotype correlation study in 118 young healthy subjects (mean age 25.8±6.7years). Subjects were genotyped for 768...

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Source

Identifiers

PMID: 21880556
DOI: 10.1016/j.dnarep.2011.08.003

Genes

XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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