Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers.

doi:10.1158/1055-9965.EPI-08-0308

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Article

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2008

Leng Shuguang, Bernauer Amanda, Stidley Christine A, Picchi Maria A, Sheng Xin, Frasco Melissa A, Van Den Berg David, Gilliland Frank D, Crowell Richard E, Belinsky Steven A

Abstract excerpt

Mutagen sensitivity in in vitro cultured lymphocytes challenged by benzo[a]pyrene diolepoxide (BPDE) has been validated as an intrinsic susceptibility factor for several cancers. Bulky BPDE-DNA adducts are repaired via either transcription-coupled repair or global genome nucleotide excision repair depending on the location of lesions. Cockayne syndrome A (CSA) and B (CSB) play essential roles in integrating the...

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PMID: 18708399
DOI: 10.1158/1055-9965.EPI-08-0308

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