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DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population.

DNA repair - 1 May 2021

Niazi Yasmeen, Thomsen Hauke, Smolkova Bozena, Vodickova Ludmila, Vodenkova Soňa, Kroupa Michal, Vymetalkova Veronika, Kazimirova Alena, Barancokova Magdalena, Volkovova Katarina, Staruchova Marta, Hoffmann Per, Nöthen Markus M, Dusinska Maria, Musak Ludovit, Vodicka Pavel, Försti Asta, Hemminki Kari

Abstract excerpt

Nonspecific structural chromosomal aberrations (CAs) can be found at around 1% of circulating lymphocytes from healthy individuals but the frequency may be higher after exposure to carcinogenic chemicals or radiation. The frequency of CAs has been measured in occupational monitoring and an increased frequency of CAs has also been associated with cancer risk. Alterations in DNA damage repair and telomere...

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PMID: 33676360
DOI: 10.1016/j.dnarep.2021.103079

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