Article
Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2007
Lin Jie, Swan Gary E, Shields Peter G, Benowitz Neal L, Gu Jian, Amos Christopher I, de Andrade Mariza, Spitz Margaret R, Wu Xifeng
Abstract excerpt
The rationale behind gene-disease association studies is that genetic variants (polymorphisms) result in alterations in intermediate phenotypes. However, genotype-phenotype correlations have not been established for most polymorphisms. In this study, we correlated genotype data of genes involved in the nucleotide excision repair pathway with mutagen sensitivity phenotype, quantified by benzo(a)pyrene diol epoxide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.