Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Polymorphisms in double strand break repair related genes influence radiosensitivity phenotype in lymphocytes from healthy individuals.

DNA repair - 1 Apr 2016

Mumbrekar Kamalesh Dattaram, Goutham Hassan Venkatesh, Vadhiraja Bejadi Manjunath, Bola Sadashiva Satish Rao

Abstract excerpt

BACKGROUND: A range of individual radiosensitivity observed in humans can influence individual's susceptibility toward cancer risk and radiotherapy outcome. Therefore, it is important to measure the variation in radiosensitivity and to identify the genetic factors influencing it. METHODS: By adopting a pathway specific genotype-phenotype design, we established the variability in cellular radiosensitivity by...

Topics

Join the communities discussing this publication.

DNA Breaks, Double-Stranded
DNA Ligase ATP
DNA Repair Enzymes
Ku Autoantigen
Lymphocytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Radiation Tolerance

Recombinational DNA Repair

Source

Identifiers

PMID: 26974709
DOI: 10.1016/j.dnarep.2016.02.006

Genes

LIG4
XRCC6
ATM
IMPACT
NBN
PRKDC
RAD51
XRCC3
XRCC4
XRCC5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms in double strand break repair related genes influence radiosensitivity phenotype in lymphocytes from healthy individuals.PMID 26974709Read ↗

What Does the History of Research on the Repair of DNA Double-Strand Breaks Tell Us?—A Comprehensive Review of Human RadiosensitivitySemantic proximity Read ↗

Genetic variations in DNA repair genes, radiosensitivity to cancer and susceptibility to acute tissue reactions in radiotherapy-treated cancer patients.Semantic proximity Read ↗

Establishing mechanisms affecting the individual response to ionizing radiationSemantic proximity Read ↗

Involvement of MRE11A and XPA gene polymorphisms in the modulation of DNA double-strand break repair activity: a genotype-phenotype correlation study.Semantic proximity Read ↗

Human Radiosensitivity and Radiosusceptibility: What Are the Differences?Semantic proximity Read ↗

Association between single nucleotide polymorphism of DNA damage repair related genes and radiosensitivity in healthy individuals.Semantic proximity Read ↗

DNA double-strand break repair capacity and normal tissue toxicity induced by radiotherapySemantic proximity Read ↗

Molecular determinants of radiosensitivity in normal and tumor tissue: A bioinformatic approach.Semantic proximity Read ↗

Factors to Consider for the Correct Use of γH2AX in the Evaluation of DNA Double-Strand Breaks Damage Caused by Ionizing RadiationSemantic proximity Read ↗

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.Semantic proximity Read ↗

G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer.Semantic proximity Read ↗

Radiogenomics helps to achieve personalized therapy by evaluating patient responses to radiation treatment.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.