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Article

Mutagen sensitivity: a genetic predisposition factor for cancer.

Cancer research - 15 Apr 2007

Wu Xifeng, Gu Jian, Spitz Margaret R

Abstract excerpt

Mutagen sensitivity, measured by quantifying the chromatid breaks induced by mutagens in short-term cultures of peripheral blood lymphocytes, has been used as an indirect measure of DNA repair capacity. Numerous epidemiologic studies have suggested that mutagen sensitivity is a cancer susceptibility factor for a variety of epithelial cancers. A recent classic twin study examined systematically the role of genetic...

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PMID: 17440053
DOI: 10.1158/0008-5472.CAN-06-4137

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