Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma.

Mutation research - 1 Jan 2000

Perez Brian S, Wong Ka Man, Schwartz Erin K, Herrera Rafael E, King Devin A, García-Nieto Pablo E, Morrison Ashby J

Abstract excerpt

Exposure to the ultraviolet (UV) radiation in sunlight creates DNA lesions, which if left unrepaired can induce mutations and contribute to skin cancer. The two most common UV-induced DNA lesions are the cis-syn cyclobutane pyrimidine dimers (CPDs) and pyrimidine (6-4) pyrimidone photoproducts (6-4PPs), both of which can initiate mutations. Interestingly, mutation frequency across the genomes of many cancers is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Euchromatin
Share to Heterochromatin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Histones

Share to Polycomb-Group Proteins

Share to Primary Cell Culture

Share to Pyrimidine Dimers

Share to Skin Neoplasms

Share to Ultraviolet Rays

Source

Open in PubMed Open full text

Identifiers

PMID: 34333390
DOI: 10.1016/j.mrfmmm.2021.111758
PMCID: PMC8671223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome-wide profiles of UV lesion susceptibility, repair, and mutagenic potential in melanoma.PMID 34333390Read ↗

Further assessment of exome-wide UVR footprints in melanoma and their possible relevance.Semantic proximity Read ↗

Deciphering UV‐induced DNA Damage Responses to Prevent and Treat Skin CancerSemantic proximity Read ↗

Mechanisms of UV-induced mutations and skin cancerSemantic proximity Read ↗

The major mechanism of melanoma mutations is based on deamination of cytosine in pyrimidine dimers as determined by circle damage sequencing.Semantic proximity Read ↗

Genomic sites hypersensitive to ultraviolet radiation.Semantic proximity Read ↗

UV damage, DNA repair and skin carcinogenesisSemantic proximity Read ↗

Oxidative Stress and Genotoxicity in Melanoma Induction: Impact on Repair Rather Than Formation of DNA Damage?Semantic proximity Read ↗

High UV damage and low repair, but not cytosine deamination, stimulate mutation hotspots at ETS binding sites in melanoma.Semantic proximity Read ↗

Skin Photodamage and Melanomagenesis: A Comprehensive ReviewSemantic proximity Read ↗

UV wavelength-dependent DNA damage and human non-melanoma and melanoma skin cancer.Semantic proximity Read ↗

Multiple interaction nodes define the postreplication repair response to UV-induced DNA damage that is defective in melanomas and correlated with UV signature mutation load.Semantic proximity Read ↗

ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.