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Article

Evaluation of genetic variation in the double-strand break repair pathway and bladder cancer risk.

Carcinogenesis - 1 Aug 2007

Figueroa Jonine D, Malats Núria, Rothman Nathaniel, Real Francisco X, Silverman Debra, Kogevinas Manolis, Chanock Stephen, Yeager Meredith, Welch Robert, Dosemeci Mustafa, Tardón Adonina, Serra Consol, Carrato Alfredo, García-Closas Reina, Castaño-Vinyals Gemma, García-Closas Montserrat

Abstract excerpt

The double-strand break DNA repair (DSBR) pathway is implicated in maintaining genomic stability and therefore could affect bladder cancer risk. Here we present data evaluating 39 single-nucleotide polymorphisms (SNPs) in seven candidate genes whose products are involved in DNA break sensing (NBS1, BRCA1 interacting genes BRIP1 and ZNF350), non-homologous end-joining (NHEJ) DNA repair (XRCC4) and homologous...

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Source

Identifiers

PMID: 17557904
DOI: 10.1093/carcin/bgm132

Genes

XRCC2
RAD51
XRCC3
XRCC4
BRCA1
BRIP1

Variants

rs861

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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