Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers.

Carcinogenesis - 1 Jul 2008

Leng Shuguang, Stidley Christine A, Bernauer Amanda M, Picchi Maria A, Sheng Xin, Frasco Melissa A, Van Den Berg David, Gilliland Frank D, Crowell Richard E, Belinsky Steven A

Abstract excerpt

The mutagen sensitivity assay is an in vitro measure of DNA repair capacity used to evaluate intrinsic susceptibility for cancer. The high heritability of mutagen sensitivity to different mutagens validates the use of this phenotype to predict cancer susceptibility. However, genetic determinants of mutagen sensitivity have not been fully characterized. Recently, several studies found that three major cytosine DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
Share to DNA (Cytosine-5-)-Methyltransferase 1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3B

Share to Lymphocytes

Share to Mutagenicity Tests

Share to Mutagens

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 18499700
DOI: 10.1093/carcin/bgn121
PMCID: PMC2899849

Genes

DNMT1
DNMT3B
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Haplotypes of DNMT1 and DNMT3B are associated with mutagen sensitivity induced by benzo[a]pyrene diol epoxide among smokers.PMID 18499700Read ↗

Association between common genetic variation in Cockayne syndrome A and B genes and nucleotide excision repair capacity among smokers.Semantic proximity Read ↗

A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens.Semantic proximity Read ↗

Mutagen sensitivity and genetic variants in nucleotide excision repair pathway: genotype-phenotype correlation.Semantic proximity Read ↗

Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.Semantic proximity Read ↗

A genetic variant near the PMAIP1/Noxa gene is associated with increased bleomycin sensitivity.Semantic proximity Read ↗

Mutagen sensitivity: a genetic predisposition factor for cancer.Semantic proximity Read ↗

Duplex sequencing identifies genomic features that determine susceptibility to benzo(a)pyrene-induced in vivo mutations.Semantic proximity Read ↗

Mutagen sensitivity as a marker of cancer susceptibility.Semantic proximity Read ↗

Mutagen sensitivity as measured by induced chromatid breakage as a marker of cancer risk.Semantic proximity Read ↗

Mutagen sensitivity has high heritability: evidence from a twin study.Semantic proximity Read ↗

Dose-Related Mutagenic and Clastogenic Effects of Benzo[b]fluoranthene in Mouse Somatic Tissues Detected by Duplex Sequencing and the Micronucleus Assay.Semantic proximity Read ↗

Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.