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Association study of genetic variation in DNA repair pathway genes and risk of basal cell carcinoma.

International journal of cancer - 1 Sept 2017

Lin Yuan, Chahal Harvind S, Wu Wenting, Cho Hyunje G, Ransohoff Katherine J, Song Fengju, Tang Jean Y, Sarin Kavita Y, Han Jiali

Abstract excerpt

DNA repair plays a critical role in protecting the genome from ultraviolet radiation and maintaining the genomic integrity of cells. Genetic variants in DNA repair-related genes can influence an individual's DNA repair capacity, which may be related to the risk of developing basal cell carcinoma (BCC). We comprehensively assessed the associations of 2,965 independent single-nucleotide polymorphisms (SNPs) across...

Topics

Carcinoma, Basal Cell
DNA Repair
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Polymorphism, Single Nucleotide
Skin Neoplasms

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Open in PubMed Open full text

Identifiers

PMID: 28510302
DOI: 10.1002/ijc.30786
PMCID: PMC5842918

Genes

MUS81
NABP2
XPA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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