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Article

A comprehensive haplotype analysis of the XPC genomic sequence reveals a cluster of genetic variants associated with sensitivity to tobacco-smoke mutagens.

Toxicological sciences : an official journal of the Society of Toxicology - 1 May 2010

Rondelli Catherine M, El-Zein Randa A, Wickliffe Jeffrey K, Etzel Carol J, Abdel-Rahman Sherif Z

Abstract excerpt

The impact of single-nucleotide polymorphisms (SNPs) of the DNA repair gene XPC on DNA repair capacity (DRC) and genotoxicity has not been comprehensively determined. We constructed a comprehensive haplotype map encompassing all common XPC SNPs and evaluated the effect of Bayesian-inferred haplotypes on DNA damage associated with tobacco smoking, using chromosome aberrations (CA) as a biomarker. We also used the...

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Identifiers

PMID: 20106949
DOI: 10.1093/toxsci/kfq027
PMCID: PMC2855352

Genes

XPC

Provenance

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