Article
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.
Nature methods - 1 Dec 2010
Baryshnikova Anastasia, Costanzo Michael, Kim Yungil, Ding Huiming, Koh Judice, Toufighi Kiana, Youn Ji-Young, Ou Jiongwen, San Luis Bryan-Joseph, Bandyopadhyay Sunayan, Hibbs Matthew, Hess David, Gingras Anne-Claude, Bader Gary D, Troyanskaya Olga G, Brown Grant W, Andrews Brenda, Boone Charles, Myers Chad L
Abstract excerpt
Global quantitative analysis of genetic interactions is a powerful approach for deciphering the roles of genes and mapping functional relationships among pathways. Using colony size as a proxy for fitness, we developed a method for measuring fitness-based genetic interactions from high-density arrays of yeast double mutants generated by synthetic genetic array (SGA) analysis. We identified several experimental...
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