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Article

Genome-Wide Quantitative Fitness Analysis (QFA) of Yeast Cultures.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2018

Holstein Eva-Maria, Lawless Conor, Banks Peter, Lydall David

Abstract excerpt

We provide a detailed protocol for robot-assisted, genome-wide measurement of fitness in the model yeast Saccharomyces cerevisiae using Quantitative Fitness Analysis (QFA). We first describe how we construct thousands of double or triple mutant yeast strains in parallel using Synthetic Genetic Array (SGA) procedures. Strains are inoculated onto solid agar surfaces by liquid spotting followed by repeated...

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PMID: 29043649
DOI: 10.1007/978-1-4939-7306-4_38

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