Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering the Genic Basis of Yeast Fitness Variation by Simultaneous Forward and Reverse Genetics.

Molecular biology and evolution - 1 Oct 2017

Maclean Calum J, Metzger Brian P H, Yang Jian-Rong, Ho Wei-Chin, Moyers Bryan, Zhang Jianzhi

Abstract excerpt

The budding yeast Saccharomyces cerevisiae is the best studied eukaryote in molecular and cell biology, but its utility for understanding the genetic basis of phenotypic variation in natural populations is limited by inefficient association mapping due to strong and complex population structure. To overcome this challenge, we generated genome sequences for 85 strains and performed a comprehensive population...

Topics

Cell Proliferation
Chromosome Mapping
Genetic Fitness
Genetic Variation
Genome, Fungal
Genome-Wide Association Study
Genomics
Phenotype
Reverse Genetics
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28472365
DOI: 10.1093/molbev/msx151

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-28472365-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering the Genic Basis of Yeast Fitness Variation by Simultaneous Forward and Reverse Genetics.PMID 28472365Read ↗

Experimental genomics of fitness in yeast.Semantic proximity Read ↗

Population-scale chemical response revealed by a barcoded yeast collection.Semantic proximity Read ↗

iSeq: A New Double-Barcode Method for Detecting Dynamic Genetic Interactions in Yeast.Semantic proximity Read ↗

A high-definition view of functional genetic variation from natural yeast genomes.Semantic proximity Read ↗

Budding Yeast Strains and Genotype-Phenotype Mapping.Semantic proximity Read ↗

The 100-genomes strains, an S. cerevisiae resource that illuminates its natural phenotypic and genotypic variation and emergence as an opportunistic pathogen.Semantic proximity Read ↗

Quantitative genetics of natural S. cerevisiae strains upon mating reveal heritable determinants of fitness and differential mating affinities.Semantic proximity Read ↗

The chemical genomic portrait of yeast: uncovering a phenotype for all genes.Semantic proximity Read ↗

High-throughput approaches to functional characterization of genetic variation in yeast.Semantic proximity Read ↗

The genotype-phenotype map of yeast complex traits: basic parameters and the role of natural selection.Semantic proximity Read ↗

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale.Semantic proximity Read ↗

Genetic complexity and quantitative trait loci mapping of yeast morphological traits.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.