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Article

τ-SGA: synthetic genetic array analysis for systematically screening and quantifying trigenic interactions in yeast.

Nature protocols - 1 Feb 2021

Kuzmin Elena, Rahman Mahfuzur, VanderSluis Benjamin, Costanzo Michael, Myers Chad L, Andrews Brenda J, Boone Charles

Abstract excerpt

Systematic complex genetic interaction studies have provided insight into high-order functional redundancies and genetic network wiring of the cell. Here, we describe a method for screening and quantifying trigenic interactions from ordered arrays of yeast strains grown on agar plates as individual colonies. The protocol instructs users on the trigenic synthetic genetic array analysis technique, τ-SGA, for...

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Identifiers

PMID: 33462440
DOI: 10.1038/s41596-020-00456-3
PMCID: PMC9127509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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