Experimental genomics of fitness in yeast.

Abstract excerpt

The set of single-gene deletions in yeast can be used to evaluate the effect of mutation on fitness over the whole genome. The measurement of growth in pure culture or relative growth in mixtures has confirmed that most deletions have little effect in laboratory culture. Moreover, there is a sharp distinction between lethality and a very mild impairment of growth, with very few intermediate cases. Different...

Topics

• Gene Deletion
• Genes, Fungal
• Genome, Fungal
• Genomics
• Mutation
• Saccharomyces cerevisiae