Article
HLA class I binding of HBZ determines outcome in HTLV-1 infection.
PLoS pathogens - 23 Sept 2010
Macnamara Aidan, Rowan Aileen, Hilburn Silva, Kadolsky Ulrich, Fujiwara Hiroshi, Suemori Koichiro, Yasukawa Masaki, Taylor Graham, Bangham Charles R M, Asquith Becca
Abstract excerpt
CD8(+) T cells can exert both protective and harmful effects on the virus-infected host. However, there is no systematic method to identify the attributes of a protective CD8(+) T cell response. Here, we combine theory and experiment to identify and quantify the contribution of all HLA class I alleles to host protection against infection with a given pathogen. In 432 HTLV-1-infected individuals we show that...
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