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Article

HLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.

PLoS medicine - 1 Oct 2006

Altfeld Marcus, Kalife Elizabeth T, Qi Ying, Streeck Hendrik, Lichterfeld Mathias, Johnston Mary N, Burgett Nicole, Swartz Martha E, Yang Amy, Alter Galit, Yu Xu G, Meier Angela, Rockstroh Juergen K, Allen Todd M, Jessen Heiko, Rosenberg Eric S, Carrington Mary, Walker Bruce D

Abstract excerpt

BACKGROUND: Very little is known about the immunodominance patterns of HIV-1-specific T cell responses during primary HIV-1 infection and the reasons for human lymphocyte antigen (HLA) modulation of disease progression. METHODS AND FINDINGS: In a cohort of 104 individuals with primary HIV-1 infection, we demonstrate that a subset of CD8(+) T cell epitopes within HIV-1 are consistently targeted early after...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to CD8-Positive T-Lymphocytes

Share to Epitopes, T-Lymphocyte

Share to Genes, MHC Class I

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Source

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Identifiers

PMID: 17076553
DOI: 10.1371/journal.pmed.0030403
PMCID: PMC1626551

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Source receipt: pubmed, retrieved 7 Sept 2026.

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