Article
Effective T-cell responses select human immunodeficiency virus mutants and slow disease progression.
Journal of virology - 1 Jun 2007
Frater A J, Brown H, Oxenius A, Günthard H F, Hirschel B, Robinson N, Leslie A J, Payne R, Crawford H, Prendergast A, Brander C, Kiepiela P, Walker B D, Goulder P J R, McLean A, Phillips R E
Abstract excerpt
The possession of some HLA class I molecules is associated with delayed progression to AIDS. The mechanism behind this beneficial effect is unclear. We tested the idea that cytotoxic T-cell responses restricted by advantageous HLA class I molecules impose stronger selection pressures than those restricted by other HLA class I alleles. As a measure of the selection pressure imposed by HLA class I alleles, we...
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