Article
HLA alleles associated with slow progression to AIDS truly prefer to present HIV-1 p24.
PloS one - 19 Sept 2007
Borghans José A M, Mølgaard Anne, de Boer Rob J, Keşmir Can
Abstract excerpt
BACKGROUND: The mechanism behind the association between human leukocyte antigen (HLA) molecules and the rate of HIV-1 disease progression is still poorly understood. Recent data suggest that "protective" HLA molecules, i.e. those associated with a low HIV-1 viral load and relatively slow disease progression, tend to present epitopes from the Gag capsid protein. Although this suggests that preferential targeting...
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