Definition of the viral targets of protective HIV-1-specific T cell responses.

doi:10.1186/1479-5876-9-208

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Article

Definition of the viral targets of protective HIV-1-specific T cell responses.

Journal of translational medicine - 7 Dec 2011

Mothe Beatriz, Llano Anuska, Ibarrondo Javier, Daniels Marcus, Miranda Cristina, Zamarreño Jennifer, Bach Vanessa, Zuniga Rosario, Pérez-Álvarez Susana, Berger Christoph T, Puertas Maria C, Martinez-Picado Javier, Rolland Morgane, Farfan Marilu, Szinger James J, Hildebrand William H, Yang Otto O, Sanchez-Merino Victor, Brumme Chanson J, Brumme Zabrina L, Heckerman David, Allen Todd M, Mullins James I, Gómez Guadalupe, Goulder Philip J, Walker Bruce D, Gatell Jose M, Clotet Bonaventura, Korber Bette T, Sanchez Jorge, Brander Christian

Abstract excerpt

BACKGROUND: The efficacy of the CTL component of a future HIV-1 vaccine will depend on the induction of responses with the most potent antiviral activity and broad HLA class I restriction. However, current HIV vaccine designs are largely based on viral sequence alignments only, not incorporating experimental data on T cell function and specificity. METHODS: Here, 950 untreated HIV-1 clade B or -C infected...

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Identifiers

PMID: 22152067
DOI: 10.1186/1479-5876-9-208
PMCID: PMC3292987

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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