HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.

doi:10.1016/j.celrep.2021.109378

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Article

HLA class-I-peptide stability mediates CD8+ T cell immunodominance hierarchies and facilitates HLA-associated immune control of HIV.

Cell reports - 13 Jul 2021

Kaseke Clarety, Park Ryan J, Singh Nishant K, Koundakjian Dylan, Bashirova Arman, Garcia Beltran Wilfredo F, Takou Mbah Overbeck C, Ma Jiaqi, Senjobe Fernando, Urbach Jonathan M, Nathan Anusha, Rossin Elizabeth J, Tano-Menka Rhoda, Khatri Ashok, Piechocka-Trocha Alicja, Waring Michael T, Birnbaum Michael E, Baker Brian M, Carrington Mary, Walker Bruce D, Gaiha Gaurav D

Abstract excerpt

Defining factors that govern CD8+ T cell immunodominance is critical for the rational design of vaccines for viral pathogens. Here, we assess the contribution of human leukocyte antigen (HLA) class-I-peptide stability for 186 optimal HIV epitopes across 18 HLA alleles using transporter associated with antigen processing (TAP)-deficient mono-allelic HLA-expressing cell lines. We find that immunodominant HIV...

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Identifiers

PMID: 34260940
DOI: 10.1016/j.celrep.2021.109378
PMCID: PMC8293625

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