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Article

Effects of thymic selection of the T-cell repertoire on HLA class I-associated control of HIV infection.

Nature - 20 May 2010

Kosmrlj Andrej, Read Elizabeth L, Qi Ying, Allen Todd M, Altfeld Marcus, Deeks Steven G, Pereyra Florencia, Carrington Mary, Walker Bruce D, Chakraborty Arup K

Abstract excerpt

Without therapy, most people infected with human immunodeficiency virus (HIV) ultimately progress to AIDS. Rare individuals ('elite controllers') maintain very low levels of HIV RNA without therapy, thereby making disease progression and transmission unlikely. Certain HLA class I alleles are markedly enriched in elite controllers, with the highest association observed for HLA-B57 (ref. 1). Because HLA molecules...

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Share to Autoantigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genes, MHC Class I

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Source

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Identifiers

PMID: 20445539
DOI: 10.1038/nature08997
PMCID: PMC3098720

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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