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Article

Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms.

Cancer research - 1 Oct 2010

Chen Gang, Giambrone Nino E, Dluzen Douglas F, Muscat Joshua E, Berg Arthur, Gallagher Carla J, Lazarus Philip

Abstract excerpt

Glucuronidation is an important pathway in the metabolism of nicotine, with previous studies suggesting that ∼22% of urinary nicotine metabolites are in the form of glucuronidated compounds. Recent in vitro studies have suggested that the UDP-glucuronosyltransferases (UGT) 2B10 and 2B17 play major roles in nicotine glucuronidation with polymorphisms in both enzymes shown to significantly alter the levels of...

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Identifiers

PMID: 20876810
DOI: 10.1158/0008-5472.CAN-09-4582
PMCID: PMC2998997

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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