Article
UGT1A and UGT2B genetic variation alters nicotine and nitrosamine glucuronidation in european and african american smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2015
Wassenaar Catherine A, Conti David V, Das Soma, Chen Peixian, Cook Edwin H, Ratain Mark J, Benowitz Neal L, Tyndale Rachel F
Abstract excerpt
BACKGROUND: Identifying sources of variation in the nicotine and nitrosamine metabolic inactivation pathways is important to understanding the relationship between smoking and cancer risk. Numerous UGT1A and UGT2B enzymes are implicated in nicotine and nitrosamine metabolism in vitro; however, little is known about their roles in vivo. METHODS: Within UGT1A1, UGT1A4, UGT1A9, UGT2B7, UGT2B10, and UGT2B17, 47...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.