Article
Impact of Genetic Variants in the Nicotine Metabolism Pathway on Nicotine Metabolite Levels in Smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 9 Jan 2023
Perez-Paramo Yadira X, Watson Christy J W, Chen Gang, Thomas Claire E, Adams-Haduch Jennifer, Wang Renwei, Khor Chiea Chuen, Koh Woon-Puay, Nelson Heather H, Yuan Jian-Min, Lazarus Philip
Abstract excerpt
BACKGROUND: Nicotine metabolism is a major factor in nicotine dependence, with approximately 70% to 80% of nicotine metabolized to cotinine in Caucasians. Cotinine formation is catalyzed primarily by CYP2A6, which also converts cotinine to trans-3'-hydroxycotinine (3HC). The goal of the present study was to examine the effects of CYP2A6 deficiency on nicotine metabolism profiles in vivo and the importance of...
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