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Article

Association between Glucuronidation Genotypes and Urinary NNAL Metabolic Phenotypes in Smokers.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jul 2016

Chen Gang, Luo Shaman, Kozlovich Shannon, Lazarus Philip

Abstract excerpt

BACKGROUND: The most abundant and potent carcinogenic tobacco-specific nitrosamine in tobacco and tobacco smoke is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). In vivo, NNK is rapidly metabolized to both the (R)- and (S)-enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), which possesses similar carcinogenic properties as NNK. The major detoxification pathway for both NNAL enantiomers is...

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PMID: 27197298
DOI: 10.1158/1055-9965.EPI-15-1245
PMCID: PMC5087993

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Source receipt: pubmed, retrieved 7 Sept 2026.

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