Article
Genetic variants in CYP2A6 and UGT1A9 genes associated with urinary nicotine metabolites in young Mexican smokers.
The pharmacogenomics journal - 1 Aug 2020
Borrego-Soto Gissela, Perez-Paramo Yadira X, Chen Gang, Santuario-Facio Sandra K, Santos-Guzman Jesus, Posadas-Valay Rodolfo, Alvarado-Monroy Fatima M, Balderas-Renteria Isaias, Medina-Gonzalez Ramses, Ortiz-Lopez Rocio, Lazarus Philip, Rojas-Martinez Augusto
Abstract excerpt
Nicotine is the major pharmacologically active substance in tobacco. Several studies have examined genotypes related to nicotine metabolism, but few studies have been performed in the Mexican population. The objective was to identify associations between gene variants in metabolizing enzymes and the urinary levels of nicotine metabolites among Mexican smokers. The levels of nicotine and its metabolites were...
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