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Article

Characterization of UDP-glucuronosyltransferase 2A1 (UGT2A1) variants and their potential role in tobacco carcinogenesis.

Pharmacogenetics and genomics - 1 Feb 2011

Bushey Ryan T, Chen Gang, Blevins-Primeau Andrea S, Krzeminski Jacek, Amin Shantu, Lazarus Philip

Abstract excerpt

OBJECTIVE: To examine UGT2A1 expression in human tissues, determine its glucuronidation activity against tobacco carcinogens, and assess the potential functional role of UGT2A1 missense single nucleotide polymorphisms on UGT2A1 enzyme activity. METHODS: Reverse transcription polymerase chain reaction and real time polymerase chain reaction were used to assess UGT2A1 gene expression in various human tissues. A...

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Source

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Identifiers

PMID: 21164388
DOI: 10.1097/FPC.0b013e328341db05
PMCID: PMC3019304

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