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Article

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.

Pharmacogenetics and genomics - 1 Dec 2013

Bloom A Joseph, von Weymarn Linda B, Martinez Maribel, Bierut Laura J, Goate Alison, Murphy Sharon E

Abstract excerpt

BACKGROUND: To develop a predictive genetic model of nicotine metabolism. UDP-glucuronosyltransferase-2B10 (UGT2B10) is the primary catalyst of nicotine glucuronidation. MATERIALS AND METHODS: The conversion of deuterated (D2)-nicotine to D2-nicotine-glucuronide, D2-cotinine, D2-cotinine-glucuronide, and D2-trans-3'-hydroxycotinine were quantified in 188 European Americans, and the contribution of UGT2B10...

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Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP2A6
Glucuronides
Glucuronosyltransferase
Nicotine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24192532
DOI: 10.1097/FPC.0000000000000011
PMCID: PMC3919513

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