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Article

Glucuronidation of trans-3′-hydroxycotinine by UGT2B17 and UGT2B10

6 Jan 2012

Abstract excerpt

OBJECTIVES: Trans-3'-Hydroxycotinine (3HC) and its glucuronide are major nicotine metabolites excreted in the urine of smokers and other tobacco users. Although several members of the UDP-glucuronosyltransferase (UGT) family of enzymes were previously shown to be active in catalyzing the formation of 3HC and its glucuronide, a comprehensive screening of all known human UGT1A and 2B enzymes for glucuronidation...

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PMID: 22228205
DOI: 10.1097/fpc.0b013e32834ff3a5

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