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Article

UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 2010

Berg Jeannette Zinggeler, von Weymarn Linda B, Thompson Elizabeth A, Wickham Katherine M, Weisensel Natalie A, Hatsukami Dorothy K, Murphy Sharon E

Abstract excerpt

BACKGROUND: Tobacco exposure is routinely assessed by quantifying nicotine metabolites in plasma or urine. On average, 80% of nicotine undergoes C-oxidation to cotinine. However, interindividual variation in nicotine glucuronidation is substantial, and glucuronidation accounts for from 0% to 40% of total nicotine metabolism. We report here the effect of a polymorphism in a UDP-glucuronsyltransferase, UGT2B10, on...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20501767
DOI: 10.1158/1055-9965.EPI-09-0959
PMCID: PMC2882998

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UGT2B10 genotype influences nicotine glucuronidation, oxidation, and consumption.PMID 20501767Read ↗

The contribution of common UGT2B10 and CYP2A6 alleles to variation in nicotine glucuronidation among European Americans.Semantic proximity Read ↗

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Effect of UGT2B10, UGT2B17, FMO3, and OCT2 genetic variation on nicotine and cotinine pharmacokinetics and smoking in African Americans.Semantic proximity Read ↗

Low Cotinine Glucuronidation Results in Higher Serum and Saliva Cotinine in African American Compared to White Smokers.Semantic proximity Read ↗

UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.Semantic proximity Read ↗

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