Article
UGT2B10 Genotype Influences Serum Cotinine Levels and Is a Primary Determinant of Higher Cotinine in African American Smokers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2020
Sipe Christopher J, Koopmeiners Joseph S, Donny Eric C, Hatsukami Dorothy K, Murphy Sharon E
Abstract excerpt
BACKGROUND: Cotinine is the most widely used biomarker of tobacco exposure. At similar smoking levels, African Americans have higher serum cotinine than Whites. UGT2B10-catalyzed cotinine glucuronidation impacts these levels, and African Americans often have low UGT2B10 activity due to a high prevalence of a UGT2B10 splice variant (rs2942857). METHODS: Two UGT2B10 SNPs (rs6175900 and rs2942857) were genotyped in...
Read the complete abstract on PubMed