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Article

Targeting tryptophan hydroxylase 2 in affective disorder.

Expert opinion on therapeutic targets - 1 Nov 2010

Popova Nina K, Kulikov Alexander V

Abstract excerpt

IMPORTANCE OF THE FIELD: Serotonin (5-HT) has been implicated in several psychiatric disorders including schizophrenia, depressive disorder and suicide. The key and rate limiting enzyme of 5-HT synthesis is tryptophan hydroxylase 2 (TPH2). AREAS COVERED IN THIS REVIEW: The association between TPH2 and affective disorders as well as future vistas of its potential clinical targeting: i) TPH2 in the regulation of...

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Source

Identifiers

PMID: 20874521
DOI: 10.1517/14728222.2010.524208

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Targeting tryptophan hydroxylase 2 in affective disorder.PMID 20874521Read ↗

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants.Semantic proximity Read ↗

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.Semantic proximity Read ↗

The tryptophan hydroxylase (TPH) 2 gene unlike TPH-1 exhibits no association with stress-induced depression.Semantic proximity Read ↗

A functional alternative splicing mutation in human tryptophan hydroxylase-2.Semantic proximity Read ↗

The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder.Semantic proximity Read ↗

Association between single nucleotide polymorphisms of TPH1 and TPH2 genes, and depressive disorders.Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder.Semantic proximity Read ↗

SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression.Semantic proximity Read ↗

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2Semantic proximity Read ↗

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