Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2

24 Dec 2005

Abstract excerpt

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in various physiological functions in both peripheral and central nervous systems (CNS). Many neuropsychiatric disorders, including depression [ 1 – 4 ], schizophrenia [ 4 – 6 ], aggression and suicidal behavior [ 1 , 6 ], attention-deficit/hyperactivity disorder (ADHD) [ 7 – 9 ], obsessive-compulsive disorder [ 10 ] and autism [ 11 ]...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Attention Deficit Hyperactivity Disorder
Share to Neurotransmitter Receptor Influence on Behavior
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 16378243
DOI: 10.1007/s00018-005-5417-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2PMID 16378243Read ↗

A functional alternative splicing mutation in human tryptophan hydroxylase-2.Semantic proximity Read ↗

Tryptophan hydroxylase-2 controls brain serotonin synthesis.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD.Semantic proximity Read ↗

Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2).Semantic proximity Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Tyrosine and tryptophan hydroxylases as therapeutic targets in human disease.Semantic proximity Read ↗

Mutations in human monoamine-related neurotransmitter pathway genes.Semantic proximity Read ↗

Genes within the serotonergic system are differentially expressed in human brain.Semantic proximity Read ↗

Characterization of a Functional Promoter Polymorphism of the Human Tryptophan Hydroxylase 2 Gene in Serotonergic Raphe NeuronsSemantic proximity Read ↗

A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system.Semantic proximity Read ↗

Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.