Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A functional alternative splicing mutation in human tryptophan hydroxylase-2.

Molecular psychiatry - 1 Dec 2011

Zhang X, Nicholls P J, Laje G, Sotnikova T D, Gainetdinov R R, Albert P R, Rajkowska G, Stockmeier C A, Speer M C, Steffens D C, Austin M C, McMahon F J, Krishnan K R R, Garcia-Blanco M A, Caron M G

Abstract excerpt

The brain serotonergic system has an essential role in the physiological functions of the central nervous system and dysregulation of serotonin (5-HT) homeostasis has been implicated in many neuropsychiatric disorders. The tryptophan hydroxylase-2 (TPH2) gene is the rate-limiting enzyme in brain 5-HT synthesis, and thus is an ideal candidate gene for understanding the role of dysregulation of brain serotonergic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Brain Stem

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cell Line, Transformed

Share to Depression

Share to PC12 Cells

Share to Serotonin

Share to Tryptophan Hydroxylase

Source

Open in PubMed Open full text

Identifiers

PMID: 20856248
DOI: 10.1038/mp.2010.99
PMCID: PMC3021090

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A functional alternative splicing mutation in human tryptophan hydroxylase-2.PMID 20856248Read ↗

Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression.Semantic proximity Read ↗

TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis.Semantic proximity Read ↗

Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2Semantic proximity Read ↗

In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders.Semantic proximity Read ↗

Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression.Semantic proximity Read ↗

Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2).Semantic proximity Read ↗

Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder.Semantic proximity Read ↗

Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.Semantic proximity Read ↗

Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2.Semantic proximity Read ↗

Functional properties of missense variants of human tryptophan hydroxylase 2Semantic proximity Read ↗

TPH2 gene polymorphisms and major depression--a meta-analysis.Semantic proximity Read ↗

Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.