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Article

Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation.

The international journal of neuropsychopharmacology - 1 Jun 2007

Gutknecht Lise, Jacob Christian, Strobel Alexander, Kriegebaum Claudia, Müller Johannes, Zeng Yong, Markert Christoph, Escher Andrea, Wendland Jens, Reif Andreas, Mössner Rainald, Gross Cornelius, Brocke Burkhard, Lesch Klaus-Peter

Abstract excerpt

Variation in the tryptophan hydroxylase-2 gene (TPH2) coding for the rate-limiting enzyme of serotonin (5-HT) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. Here, we tested a set of common single nucleotide polymorphisms (SNPs) in and downstream of the transcriptional control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17176492
DOI: 10.1017/S1461145706007437

Genes

TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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