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Article

Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.

PLoS genetics - 9 Sept 2010

Chuang Chen-Hua, Wallace Marsha D, Abratte Christian, Southard Teresa, Schimenti John C

Abstract excerpt

Mutations causing replication stress can lead to genomic instability (GIN). In vitro studies have shown that drastic depletion of the MCM2-7 DNA replication licensing factors, which form the replicative helicase, can cause GIN and cell proliferation defects that are exacerbated under conditions of replication stress. To explore the effects of incrementally attenuated replication licensing in whole animals, we...

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Identifiers

PMID: 20838603
DOI: 10.1371/journal.pgen.1001110
PMCID: PMC2936539

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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