Article

Elevated Levels of Mcm7 Disrupt Microtubule and Nucleolar Homeostasis to Drive Genome Instability and Cell Death

2026-08-03

Abstract excerpt

Overexpression of pre-replication complex (pre-RC) components is frequently associated with poor prognosis in many types of cancer, yet the mechanisms underlying their pathological effects remain unclear. Using the model yeast Candida albicans , we investigated the consequences of elevated Mcm7 levels, a conserved pre-RC subunit previously linked to c hromosome in stability (CIN). Unlike other pre-RC components...

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Literature Corpus work: cc909270-f58e-57fc-99d0-69cfb1ad4692
DOI: 10.64898/2026.07.31.742030

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