Article
A dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesis.
PLoS genetics - 1 Jan 2012
Bagley Bruce N, Keane Thomas M, Maklakova Vilena I, Marshall Jonathon G, Lester Rachael A, Cancel Michelle M, Paulsen Alex R, Bendzick Laura E, Been Raha A, Kogan Scott C, Cormier Robert T, Kendziorski Christina, Adams David J, Collier Lara S
Abstract excerpt
Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma (T-ALL) called Spontaneous dominant leukemia (Sdl). Sdl heterozygous mice develop disease with a short latency and high penetrance, while mice homozygous for the mutation die early during embryonic development. Sdl mice exhibit an increase in the frequency of micronucleated reticulocytes, and T-ALLs from Sdl mice...
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