Article
Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.
Molecular cell - 4 Mar 2011
Kawabata Tsuyoshi, Luebben Spencer W, Yamaguchi Satoru, Ilves Ivar, Matise Ilze, Buske Tavanna, Botchan Michael R, Shima Naoko
Abstract excerpt
Eukaryotic cells license far more origins than are actually used for DNA replication, thereby generating a large number of dormant origins. Accumulating evidence suggests that such origins play a role in chromosome stability and tumor suppression, though the underlying mechanism is largely unknown. Here, we show that a loss of dormant origins results in an increased number of stalled replication forks, even in...
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