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Article

Functional screen of human MCM2-7 variant alleles for disease-causing potential.

Mutation research - 18 Jun 2009

Steere Nathan A, Yamaguchi Satoru, Andrews Catherine A, Liachko Ivan, Nakamura Tomoka, Shima Naoko

Abstract excerpt

Origin licensing builds a fundamental basis for genome stability in DNA replication. Recent studies reported that deregulation of origin licensing is associated with replication stress in precancerous lesions. The heterohexameric complex of minichromosome maintenance proteins (MCM2-7 complex) plays an essential role in origin licensing. Previously, we reported the recovery of the first viable Mcm mutant allele...

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Source

Identifiers

PMID: 19481678
DOI: 10.1016/j.mrfmmm.2009.03.006

Genes

MCM2
MCM5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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