Article
Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.
Nucleic acids research - 1 Jun 2012
Chuang Chen-Hua, Yang Dian, Bai Gongshi, Freeland Amy, Pruitt Steven C, Schimenti John C
Abstract excerpt
The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic instability (GIN), leading to cancer and developmental defects in mice. Remarkably, depletion or mutation of one Mcm can decrease all Mcm levels. Here, we use mice and cells bearing a GIN-causing hypomophic allele of Mcm4 (Chaos3), in conjunction with...
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