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Article

Ploidy dictates repair pathway choice under DNA replication stress.

Genetics - 1 Apr 2011

Li Xin Chenglin, Tye Bik K

Abstract excerpt

This study reports an unusual ploidy-specific response to replication stress presented by a defective minichromosome maintenance (MCM) helicase allele in yeast. The corresponding mouse allele, Mcm4(Chaos3), predisposes mice to mammary gland tumors. While mcm4(Chaos3) causes replication stress in both haploid and diploid yeast, only diploid mutants exhibit G2/M delay, severe genetic instability (GIN), and reduced...

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Identifiers

PMID: 21242538
DOI: 10.1534/genetics.110.125450
PMCID: PMC3070513

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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