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Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

12 Oct 2015

Abstract excerpt

Replicative stress during embryonic development influences ageing and predisposition to disease in adults. A protective mechanism against replicative stress is provided by the licensing of thousands of origins in G1 that are not necessarily activated in the subsequent S-phase. These 'dormant' origins provide a backup in the presence of stalled forks and may confer flexibility to the replication program in...

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Share to Epigenetics and DNA Methylation
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PMID: 26456157
DOI: 10.1038/ncomms9548

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