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Article

Genetic screen for chromosome instability in mice: Mcm4 and breast cancer.

Cell cycle (Georgetown, Tex.) - 15 May 2007

Shima Naoko, Buske Tavanna R, Schimenti John C

Abstract excerpt

We recently isolated a hypomorphic mutation of Mcm4 in a phenotype-based screen for chromosome instability in mice. This mutation, named Chaos3 (chromosome aberrations occurring spontaneously 3), causes exclusively mammary adenocarcinomas in approximately 80% of homozygous females. Mcm4 encodes a subunit of the MCM2-7 complex, the replication-licensing factor and the replicative helicase. The Mcm4(Chaos3)...

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Source

Identifiers

PMID: 17495541
DOI: 10.4161/cc.6.10.4250

Genes

MCM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Genetic screen for chromosome instability in mice: Mcm4 and breast cancer.PMID 17495541Read ↗

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