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Reduced Mcm2 Expression Results in Severe Stem/Progenitor Cell Deficiency and Cancer

23 Aug 2007

Abstract excerpt

Mcm2 is a component of the DNA replication licensing complex that marks DNA replication origins during G1 of the cell cycle for use in the subsequent S-phase. It is expressed in stem/progenitor cells in a variety of regenerative tissues in mammals. Here, we have used the Mcm2 gene to develop a transgenic mouse in which somatic stem/progenitor cells can be genetically modified in the adult. In these mice, a...

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PMID: 17717065
DOI: 10.1634/stemcells.2007-0483

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