Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses.

Nucleic acids research - 1 Jan 2011

Sugiyama Ryuichi, Hayafune Masaaki, Habu Yuichiro, Yamamoto Norio, Takaku Hiroshi

Abstract excerpt

DNAzymes are easier to prepare and less sensitive to chemical and enzymatic degradation than ribozymes; however, a DNA enzyme expression system has not yet been developed. In this study, we exploited the mechanism of HIV-1 reverse transcription (RT) in a DNA enzyme expression system. We construct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Catalytic
Share to env Gene Products, Human Immunodeficiency Virus
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lentivirus

Share to Reverse Transcription

Share to RNA, Small Interfering

Share to RNA, Transfer

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 20833635
DOI: 10.1093/nar/gkq794
PMCID: PMC3025543

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20833635-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HIV-1 RT-dependent DNAzyme expression inhibits HIV-1 replication without the emergence of escape viruses.PMID 20833635Read ↗

RNA cleaving '10-23' DNAzymes with enhanced stability and activity.Semantic proximity Read ↗

Engineering the Activity of a Template-Independent DNA Polymerase.Semantic proximity Read ↗

HIV-1 inactivation by nucleic acid aptamersSemantic proximity Read ↗

Detection of treatment-resistant infectious HIV after genome-directed antiviral endonuclease therapy.Semantic proximity Read ↗

Deaminase-independent inhibition of HIV-1 reverse transcription by APOBEC3GSemantic proximity Read ↗

HIV-1 proviral DNA excision using an evolved recombinase.Semantic proximity Read ↗

Mechanism of DNA strand transfer reactions catalyzed by HIV-1 reverse transcriptase.Semantic proximity Read ↗

A new and efficient DNA enzyme for the sequence-specific cleavage of RNA.Semantic proximity Read ↗

In vitro selection of ribozymes dependent on peptides for activity.Semantic proximity Read ↗

Biochemical, inhibition and inhibitor resistance studies of xenotropic murine leukemia virus-related virus reverse transcriptase.Semantic proximity Read ↗

Mechanism and fidelity of HIV reverse transcriptase.Semantic proximity Read ↗

DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.