Article
In vitro selection of ribozymes dependent on peptides for activity.
RNA (New York, N.Y.) - 1 Jan 2004
Robertson Michael P, Knudsen Scott M, Ellington Andrew D
Abstract excerpt
A peptide-dependent ribozyme ligase (aptazyme ligase) has been selected from a random sequence population based on the small L1 ligase. The aptazyme ligase is activated > 18,000-fold by its cognate peptide effector, the HIV-1 Rev arginine-rich motif (ARM), and specifically recognizes the Rev ARM relative to other peptides containing arginine-rich motifs. Moreover, the aptazyme ligase can preferentially recognize...
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